Acetylated, methylated, remodeled: chromatin states for gene regulation

Curr Opin Plant Biol. 2002 Oct;5(5):437-43. doi: 10.1016/s1369-5266(02)00287-x.

Abstract

The activity state of a gene is determined not only by sequence-specific regulatory factors but also by a complex network of co-acting proteins. Many of these proteins directly or indirectly affect the structure of the chromatin environment into which the gene is embedded. Recent studies of histone and DNA modifications support and refine the concept of the chromatin environment being key to the establishment and maintenance of transcriptional activity or repression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / metabolism
  • Amino Acid Sequence
  • Chromatin / chemistry
  • Chromatin / genetics*
  • Chromatin / metabolism*
  • DNA Methylation*
  • Energy Metabolism
  • Gene Expression Regulation, Plant*
  • Histone Acetyltransferases
  • Histone Deacetylases / metabolism
  • Histones / chemistry
  • Histones / metabolism
  • Plants / genetics*
  • Plants / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Chromatin
  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases
  • Histone Deacetylases