Abstract
We investigated the contribution of Candida albicans ALS1, which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Candida albicans / genetics*
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Candida albicans / pathogenicity*
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Candidiasis, Oral / etiology*
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Candidiasis, Oral / microbiology
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Candidiasis, Oral / pathology
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Cell Adhesion / genetics
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Cell Adhesion / physiology
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Fungal Proteins / genetics*
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Fungal Proteins / physiology*
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In Vitro Techniques
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Mice
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Mutation
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Tongue / microbiology
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Virulence / genetics
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Virulence / physiology
Substances
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ALS1 protein, Candida albicans
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Fungal Proteins