Abstract
GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD(1a)-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD(1a)-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, Bacterial / genetics
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Base Sequence
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Campylobacter jejuni / genetics
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Campylobacter jejuni / immunology*
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Campylobacter jejuni / pathogenicity*
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DNA, Bacterial / genetics
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Epitopes / genetics
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G(M1) Ganglioside / genetics
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G(M1) Ganglioside / immunology
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Gangliosides / genetics
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Gangliosides / immunology*
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Gene Expression
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Genes, Bacterial
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Guillain-Barre Syndrome / etiology
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Guillain-Barre Syndrome / microbiology*
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Humans
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Lipopolysaccharides / immunology
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Molecular Mimicry
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Risk Factors
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Virulence / genetics
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Virulence / immunology
Substances
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Antigens, Bacterial
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DNA, Bacterial
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Epitopes
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Gangliosides
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Lipopolysaccharides
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lipid-linked oligosaccharides
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ganglioside, GD1a
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G(M1) Ganglioside