To ERR in the estrogen pathway

Trends Endocrinol Metab. 2002 Jul;13(5):220-5. doi: 10.1016/s1043-2760(02)00592-1.


Estrogens control a variety of physiological and disease-linked processes, most notably reproduction, bone remodeling and breast cancer, and their effects are transduced through classic unclear receptors referred to as estrogen receptor-alpha (ER alpha) and ER beta. Recent results obtained using the estrogen-related receptors (ERR alpha, -beta and -gamma), a subfamily of orphan nuclear receptors closely related to the ERs, have shown that the ERRs share target genes, coregulatory proteins, ligands and sites of action with the ERs. In addition, the ERRs can actively influence the estrogenic response, suggesting that pharmacological modulation of ERR activity will be clinically useful to prevent and/or treat a variety of conditions related to women's health.

Publication types

  • Review

MeSH terms

  • Bone Remodeling / physiology
  • Breast Neoplasms / metabolism
  • Estradiol / metabolism
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Estrogens / metabolism*
  • Female
  • Humans
  • Ligands
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Estrogen / metabolism*


  • ERRalpha estrogen-related receptor
  • ESRRB protein, human
  • ESRRG protein, human
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Estrogens
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Estrogen
  • estrogen receptor-related receptor beta
  • Estradiol