Attachment and tension in the spindle assembly checkpoint

J Cell Sci. 2002 Sep 15;115(Pt 18):3547-55. doi: 10.1242/jcs.00029.

Abstract

Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay chromosome segregation. Only when all the chromosomes are attached by kinetochore microtubules from two opposite spindle poles and proper tension is placed on the paired kinetochores does anaphase take place, allowing the physical splitting of sister chromatids. Recent studies have provided novel insights into the molecular mechanisms through which the spindle assembly checkpoint is regulated by both the attachment of chromosomes to kinetochore microtubules and the tension exerted on kinetochores.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromosome Segregation / genetics
  • Eukaryotic Cells / metabolism*
  • Genes, cdc / physiology*
  • Humans
  • Kinetochores / metabolism*
  • Microtubules / genetics
  • Microtubules / metabolism
  • Mitosis / physiology*
  • Signal Transduction / genetics
  • Spindle Apparatus / metabolism*
  • Stress, Mechanical

Substances

  • Cell Cycle Proteins