[Mechanisms of atrial fibrillation]

Rev Prat. 2002 Jun 15;52(12):1301-6.
[Article in French]


Atrial fibrillation occurs because of a complex interaction between an arrhythmogenic substrate, triggers factors and the autonomic nervous system. Underlying fundamental mechanisms are multiple, can cohabit and include schematically: multiple wavelet, stable microreentry, macro single meandering spiral wave reentry and focal atrial fibrillation arising from the pulmonary veins. More over, new concepts have emerged like the atrial fibrillation-induced electrical and structural remodeling which favors its own perpetuation. Experimental studies have shown a complex interaction between anatomical particularities of the atria and the activation fronts dynamic. All this recent progress open new and more efficient therapeutic perspectives for patients enduring atrial fibrillation.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Atrial Fibrillation / physiopathology*
  • Atrial Fibrillation / therapy
  • Autonomic Nervous System / physiology
  • Defibrillators, Implantable
  • Heart Atria / pathology
  • Humans