Adjacent vertebral failure after vertebroplasty. A biomechanical investigation

J Bone Joint Surg Br. 2002 Jul;84(5):748-52. doi: 10.1302/0301-620x.84b5.11841.


Vertebroplasty, which is the percutaneous injection of bone cement into vertebral bodies has recently been used to treat painful osteoporotic compression fractures. Early clinical results have been encouraging, but very little is known about the consequences of augmentation with cement for the adjacent, non-augmented level. We therefore measured the overall failure, strength and structural stiffness of paired osteoporotic two-vertebra functional spine units (FSUs). One FSU of each pair was augmented with polymethylmethacrylate bone cement in the caudal vertebra, while the other served as an untreated control. Compared with the controls, the ultimate failure load for FSUs treated by injection of cement was lower. The geometric mean treated/untreated ratio of failure load was 0.81, with 95% confidence limits from 0.70 to 0.92, (p < 0.01). There was no significant difference in overall FSU stiffness. For treated FSUs, there was a trend towards lower failure loads with increased filling with cement (r2 = 0.262, p = 0.13). The current practice of maximum filling with cement to restore the stiffness and strength of a vertebral body may provoke fractures in adjacent, non-augmented vertebrae. Further investigation is required to determine an optimal protocol for augmentation.

MeSH terms

  • Biomechanical Phenomena
  • Bone Cements / adverse effects*
  • Cementation / methods
  • Humans
  • Osteoporosis / complications
  • Osteoporosis / physiopathology
  • Polymethyl Methacrylate / adverse effects*
  • Spinal Fractures / etiology*
  • Spinal Fractures / physiopathology
  • Spinal Fractures / therapy*
  • Spine / physiopathology


  • Bone Cements
  • Polymethyl Methacrylate