Drug target discovery by gene expression analysis: cell cycle genes

Curr Cancer Drug Targets. 2001 May;1(1):73-83. doi: 10.2174/1568009013334241.


Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drug's mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Drug Design*
  • Forecasting
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Molecular Sequence Data
  • Neoplasms / genetics*
  • Oligonucleotide Array Sequence Analysis
  • RNA, Messenger / metabolism


  • Cell Cycle Proteins
  • RNA, Messenger

Associated data

  • GENBANK/BG354574
  • GENBANK/BG354575
  • GENBANK/BG354576
  • GENBANK/BG354577
  • GENBANK/BG354578
  • GENBANK/BG354579
  • GENBANK/BG354580
  • GENBANK/BG354581