Coincidence of Behçet's disease and SAPHO syndrome

Clin Rheumatol. 2002 Aug;21(4):324-7. doi: 10.1007/s100670200085.


A young woman presented with deteriorated visual acuity due to acute retinal vasculitis. The diagnosis of Behçet's disease was made on the basis of the ophthalmologic findings and recurrent oral and genital aphthous ulcerations. In the past, this young woman had been operated on several times because of progressive aseptic osteitis of the right clavicle. The actual examination revealed chronic osteitis, osteosclerosis and hyperostosis of the anterior chest wall, as well as severe acne papulopustulosa et conglobata. These findings resulted in an additional diagnosis of SAPHO syndrome. This report is the first description of Behçet's disease occurring in association with SAPHO syndrome, both fulfilling the diagnostic criteria.

Publication types

  • Case Reports

MeSH terms

  • Acquired Hyperostosis Syndrome / complications*
  • Acquired Hyperostosis Syndrome / drug therapy
  • Acquired Hyperostosis Syndrome / pathology
  • Administration, Oral
  • Adolescent
  • Behcet Syndrome / complications*
  • Behcet Syndrome / drug therapy
  • Behcet Syndrome / pathology
  • Clavicle / diagnostic imaging
  • Cyclophosphamide / therapeutic use
  • Cyclosporine / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Prednisone / administration & dosage
  • Prednisone / therapeutic use
  • Radiography, Thoracic
  • Radionuclide Imaging
  • Technetium Tc 99m Medronate
  • Treatment Outcome


  • Immunosuppressive Agents
  • Cyclosporine
  • Cyclophosphamide
  • Prednisone
  • Technetium Tc 99m Medronate