Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain

Pathology. 2002 Aug;34(4):344-7. doi: 10.1080/003130202760120517.

Abstract

Aims: To study the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains.

Methods: Using a purpose-designed exposure system at 900 MHz, mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0,2.0 and 4.0 W/kg. Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects. Albumin immunohistochemistry was used to detect increased vascular permeability and the efficacy of the vascular tracer was confirmed with a positive control group exposed to a clostridial toxin known to increase vascular permeability in the brain.

Results: In all exposed and control groups, albumin extravasation was minimal, often leptomeningeal, and was deemed insignificant as a maximum of three capillaries or venules in a given brain showed leakage from the very many blood vessels present in the three coronal brain sections.

Conclusions: These results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level using endogenous albumin as a vascular tracer.

MeSH terms

  • Animals
  • Capillary Permeability*
  • Cell Phone*
  • Cerebrovascular Circulation / radiation effects*
  • Female
  • Immunohistochemistry
  • Mice
  • Mice, Inbred C57BL
  • Microwaves / adverse effects*
  • Serum Albumin / metabolism

Substances

  • Serum Albumin