An ESCRT into the endosome

Elizabeth Conibear

doi:10.1016/s1097-2765(02)00601-9

An ESCRT into the endosome

Mol Cell. 2002 Aug;10(2):215-6. doi: 10.1016/s1097-2765(02)00601-9.

Author

Elizabeth Conibear¹

Affiliation

¹ Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

PMID: 12191463
DOI: 10.1016/s1097-2765(02)00601-9

Abstract

Multivesicular endosomes sort ubiquitinated membrane proteins for degradation by incorporating them into inwardly budding vesicles. The recent identification of two new oligomeric components of the sorting machinery gives us a detailed view of the complex protein-protein interactions driving this process.

MeSH terms

Animals
Biological Transport
Carrier Proteins / metabolism*
Clathrin / metabolism
Endosomes / metabolism*
Humans
Macromolecular Substances
Membrane Proteins / metabolism
Protein Transport
Ubiquitin / metabolism

Substances

Carrier Proteins
Clathrin
Macromolecular Substances
Membrane Proteins
Ubiquitin