Delivery of nascent polypeptides to the mitochondrial surface

Biochim Biophys Acta. 2002 Sep 2;1592(1):35-9. doi: 10.1016/s0167-4889(02)00262-8.

Abstract

Thousands of polypeptides with diverse biochemical properties, some of which are extremely hydrophobic, are targeted from cytoplasmic ribosomes to the surface of mitochondria. Localised synthesis, as well as transient interactions with a wide array of molecular chaperones and other cytoplasmic factors, can promote productive interaction of mitochondrial proteins with the TOM complex to initiate protein import into mitochondria.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carrier Proteins / metabolism
  • Cytoplasm / metabolism
  • Eukaryotic Cells
  • Intracellular Membranes / metabolism*
  • Mitochondria / metabolism*
  • Mitochondrial Proteins / biosynthesis
  • Mitochondrial Proteins / metabolism*
  • Molecular Chaperones / metabolism
  • Peptides / chemistry
  • Peptides / metabolism*
  • Protein Biosynthesis
  • Protein Precursors / metabolism*
  • Protein Processing, Post-Translational
  • Protein Transport
  • Ribosomes / metabolism

Substances

  • Carrier Proteins
  • Mitochondrial Proteins
  • Molecular Chaperones
  • Peptides
  • Protein Precursors
  • TOM translocase