Multimodal target point assessment for stereotactic biopsy in children with diffuse bithalamic astrocytomas

Childs Nerv Syst. 2002 Aug;18(8):445-9. doi: 10.1007/s00381-002-0644-6. Epub 2002 Jul 26.


Introduction: Diffuse glial tumors with bithalamic involvement are rare in children. Diagnostic assessment can be difficult as the radiological findings can be unspecific.

Materials and methods: In order to enhance the diagnostic yield metabolic imaging with MRS and PET using FET ( O-(2-[(18)F]fluoroethyl)- L-tyrosine) was performed in two children (2 and 10 years of age). Co-registered images were used for image-guided biopsy, which was planned with neuronavigation and stereotaxy simultaneously.

Results: Biopsies from the right thalamus were planned, but locations were changed in both cases after metabolic imaging was available. MRS (thalamic voxel) was typical for a glial tumor in one child. In the older girl FET-PET revealed an unexpected lesion in the left cerebellar hemisphere, with a tumor-to-cortex ratio of 3.8, as against 1.7 in the thalamus. Accordingly, a stereotactic biopsy specimen was taken from the left cerebellar hemisphere, and a final diagnosis of anaplastic astrocytoma was made. The other patient showed a higher uptake (tumor-to-cortex ratio 1.6) in the left dorsal thalamus, compared with bilateral homogeneous hyperintensity of the thalamus structures on MRI. Stereotactic biopsy revealed a low-grade diffuse astrocytoma.

Conclusion: Stereotactic biopsy using metabolic imaging and image fusion can enhance the diagnostic yield in cases of diffuse pediatric gliomas disclosing unexpected 'hot spots'.

Publication types

  • Case Reports

MeSH terms

  • Astrocytoma / diagnostic imaging
  • Astrocytoma / pathology*
  • Biopsy / methods
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology*
  • Child
  • Child, Preschool
  • Female
  • Fluorine Radioisotopes
  • Glioblastoma / diagnostic imaging
  • Glioblastoma / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Stereotaxic Techniques
  • Thalamus / diagnostic imaging
  • Thalamus / pathology*
  • Tomography, Emission-Computed


  • Fluorine Radioisotopes