Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae

Funct Integr Genomics. 2002 Sep;2(4-5):154-70. doi: 10.1007/s10142-002-0060-8. Epub 2002 Jun 5.


On the basis of functional and phylogenetic criteria, we have identified a total of 229 subfamilies and 111 singletons predicted to carry out transport or other membrane functions in Saccharomyces cerevisiae. We have extended the Transporter Classification (TC) and created a Membrane Classification (MC) for non-transporter membrane proteins. Using the preliminary phylogenetic digits X, Y, Z (for new families, subfamilies, and clusters, respectively), we allocated a five-digit number to 850 proteins predicted to contain more than two transmembrane domains. Compared with a previous TC of the yeast genome, we classified an additional set of 538 membrane proteins (transporters and non-transporters) and identified 111 novel phylogenetic subfamilies.

Publication types

  • Review

MeSH terms

  • Membrane Proteins / classification*
  • Membrane Proteins / metabolism
  • Phylogeny*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / classification*
  • Saccharomyces cerevisiae Proteins / metabolism


  • Membrane Proteins
  • Saccharomyces cerevisiae Proteins