Abstract
Two new minor tribromodibenzo-p-dioxins, spongiadioxin C (1) and its methyl ether (2), were isolated from an Australian marine sponge Dysidea dendyi, together with the known minor metabolites methyl ethers of spongiadioxins A (4) and B (6) and polybrominated diphenyl ethers (7-9). The structures of the new compounds were established by 1D and 2D NMR spectroscopy and confirmed by synthesis of 2 from diphenyl ether 9. All isolated compounds inhibited the cell division of fertilized sea urchin eggs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Division / drug effects
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Dioxins / chemistry
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Dioxins / isolation & purification*
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Dioxins / pharmacology
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Eggs
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Hydrocarbons, Brominated / chemistry
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Hydrocarbons, Brominated / isolation & purification*
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Hydrocarbons, Brominated / pharmacology
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Inhibitory Concentration 50
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Methylation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenyl Ethers
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Porifera / chemistry*
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Sea Urchins / drug effects
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Spectrometry, Mass, Electrospray Ionization
Substances
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Dioxins
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Hydrocarbons, Brominated
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Phenyl Ethers
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spongiadioxin A
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spongiadioxin B
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spongiadioxin C
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spongiadioxin C, methyl ether
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phenyl ether