Axon guidance: proteins turnover in turning growth cones

Curr Biol. 2002 Aug 20;12(16):R560-2. doi: 10.1016/s0960-9822(02)01054-0.

Abstract

Accurate navigation by a neuronal growth cone requires the modulation of the growth cone's responsiveness to spatial and temporal changes in expression of guidance cues. These adaptations involve local protein synthesis and turnover in growth cones and distal axons.

MeSH terms

  • Animals
  • Axons / metabolism
  • Axons / physiology*
  • Cell Movement
  • Chemotactic Factors / metabolism
  • Chickens
  • Growth Cones / metabolism
  • Growth Cones / physiology*
  • Protein Biosynthesis
  • Proteins / metabolism*
  • Retinal Ganglion Cells / cytology
  • Retinal Ganglion Cells / physiology
  • Xenopus laevis

Substances

  • Chemotactic Factors
  • Proteins