Function and regulation of CREB family transcription factors in the nervous system

Neuron. 2002 Aug 15;35(4):605-23. doi: 10.1016/s0896-6273(02)00828-0.


CREB and its close relatives are now widely accepted as prototypical stimulus-inducible transcription factors. In many cell types, these factors function as effector molecules that bring about cellular changes in response to discrete sets of instructions. In neurons, a wide range of extracellular stimuli are capable of activating CREB family members, and CREB-dependent gene expression has been implicated in complex and diverse processes ranging from development to plasticity to disease. In this review, we focus on the current level of understanding of where, when, and how CREB family members function in the nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System Diseases / genetics
  • Central Nervous System Diseases / metabolism
  • Central Nervous System Diseases / physiopathology
  • Circadian Rhythm / genetics
  • Cyclic AMP Response Element-Binding Protein / genetics
  • Cyclic AMP Response Element-Binding Protein / metabolism*
  • Gene Expression Regulation, Developmental / genetics
  • Humans
  • Memory / physiology
  • Nervous System / cytology
  • Nervous System / embryology
  • Nervous System / metabolism*
  • Neural Pathways / cytology
  • Neural Pathways / embryology
  • Neural Pathways / metabolism*
  • Neuronal Plasticity / genetics
  • Neurons / cytology
  • Neurons / metabolism*
  • Signal Transduction / genetics*


  • Cyclic AMP Response Element-Binding Protein