Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa

Neuro Endocrinol Lett. 2002 Aug;23(4):365-8.


We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphological structure. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Electric Conductivity
  • Electroretinography
  • Humans
  • Middle Aged
  • Oligopeptides / administration & dosage*
  • Pineal Gland / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Retina / pathology
  • Retina / physiology
  • Retinitis Pigmentosa / drug therapy*
  • Retinitis Pigmentosa / pathology


  • Oligopeptides
  • alanyl-glutamyl-aspartyl-glycine