Spatial memory dissociations in mice lacking GluR1

Nat Neurosci. 2002 Sep;5(9):868-73. doi: 10.1038/nn910.


Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, both on the hidden platform watermaze task and on an appetitively motivated Y-maze task. In contrast, they showed a specific spatial working memory impairment during tests of non-matching to place on both the Y-maze and an elevated T-maze. In addition, successful watermaze and Y-maze reference memory performance depended on hippocampal function in both wild-type and mutant mice; bilateral hippocampal lesions profoundly impaired performance on both tasks, to a similar extent in both groups. These results suggest that different forms of hippocampus-dependent spatial memory involve different aspects of neural processing within the hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Hippocampus / physiopathology*
  • Long-Term Potentiation / genetics*
  • Male
  • Maze Learning / physiology*
  • Memory Disorders / genetics
  • Memory Disorders / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mutation / genetics
  • Neural Pathways / physiopathology*
  • Neurons / metabolism
  • Receptors, AMPA / deficiency*
  • Receptors, AMPA / genetics
  • Space Perception / physiology*
  • Synapses / metabolism
  • Synaptic Transmission / physiology


  • Receptors, AMPA
  • glutamate receptor ionotropic, AMPA 1