The biosynthesis of adenosylcobalamin (vitamin B12)

Nat Prod Rep. 2002 Aug;19(4):390-412. doi: 10.1039/b108967f.

Abstract

Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacteria / metabolism*
  • Catalysis
  • Cobalt / metabolism
  • Cobamides / metabolism
  • Cyclization
  • Genes, Bacterial
  • Methyltransferases / chemistry
  • Methyltransferases / metabolism
  • Molecular Structure
  • Nucleotidyltransferases / metabolism
  • Protein Conformation
  • Uroporphyrinogens / biosynthesis*
  • Uroporphyrinogens / chemistry*
  • Uroporphyrins / biosynthesis
  • Uroporphyrins / chemistry
  • Vitamin B 12* / analogs & derivatives
  • Vitamin B 12* / biosynthesis
  • Vitamin B 12* / chemistry

Substances

  • Cobamides
  • Uroporphyrinogens
  • Uroporphyrins
  • Cobalt
  • Methyltransferases
  • Nucleotidyltransferases
  • guanylyltransferase
  • cobamamide
  • Vitamin B 12