Survival-promoting functions of 14-3-3 proteins

Biochem Soc Trans. 2002 Aug;30(4):360-5. doi: 10.1042/bst0300360.


The 14-3-3 proteins are a family of phosphoserine/phosphothreonine-binding molecules that control the function of a wide array of cellular proteins. We suggest that one function of 14-3-3 is to support cell survival. 14-3-3 proteins promote survival in part by antagonizing the activity of associated proapoptotic proteins, including Bad and apoptosis signal-regulating kinase 1 (ASK1). Indeed, expression of 14-3-3 inhibitor peptides in cells is sufficient to induce apoptosis. Interestingly, these 14-3-3 antagonist peptides can sensitize cells for effective killing by anticancer agents such as cisplatin. Thus, 14-3-3 may be part of the cellular machinery that maintains cell survival, and targeting 14-3-3-ligand interactions may be a useful strategy to enhance the efficacy of conventional anticancer agents.

Publication types

  • Review

MeSH terms

  • 14-3-3 Proteins
  • Animals
  • Apoptosis / physiology*
  • Cell Survival / physiology*
  • Homeostasis
  • Humans
  • MAP Kinase Signaling System
  • Phosphoproteins / physiology
  • Phosphorylation
  • Signal Transduction
  • Tyrosine 3-Monooxygenase / physiology*


  • 14-3-3 Proteins
  • Phosphoproteins
  • Tyrosine 3-Monooxygenase