Calcium-D-glucarate

Altern Med Rev. 2002 Aug;7(4):336-9.

Abstract

Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers. Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents* / metabolism
  • Anticarcinogenic Agents* / pharmacology
  • Anticarcinogenic Agents* / therapeutic use
  • Anticholesteremic Agents / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / prevention & control
  • Colonic Neoplasms / drug therapy
  • Colonic Neoplasms / prevention & control
  • Estrogens / metabolism
  • Glucaric Acid* / metabolism
  • Glucaric Acid* / pharmacology
  • Glucaric Acid* / therapeutic use
  • Humans
  • Hyperlipidemias / drug therapy
  • Hyperlipidemias / prevention & control
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / prevention & control
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / prevention & control
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / prevention & control

Substances

  • Anticarcinogenic Agents
  • Anticholesteremic Agents
  • Estrogens
  • Glucaric Acid