Intramembrane Proteolysis Controls Diverse Signalling Pathways Throughout Evolution

Curr Opin Genet Dev. 2002 Oct;12(5):512-8. doi: 10.1016/s0959-437x(02)00334-9.


Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • Cell Communication
  • Cell Nucleus / metabolism*
  • Cysteine Endopeptidases / metabolism
  • Cytoplasm / physiology
  • Endopeptidases / metabolism*
  • Evolution, Molecular*
  • Humans
  • Intracellular Membranes / metabolism*
  • Multienzyme Complexes / metabolism
  • Proteasome Endopeptidase Complex
  • Signal Transduction*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • Multienzyme Complexes
  • Transcription Factors
  • Endopeptidases
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex