CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

Curr Opin Genet Dev. 2002 Oct;12(5):524-33. doi: 10.1016/s0959-437x(02)00336-2.

Abstract

During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Drosophila Proteins
  • Drosophila melanogaster / embryology
  • Gene Expression Regulation, Developmental
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Receptors, Notch
  • Signal Transduction
  • Wings, Animal / embryology*

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch