Why size matters: altering cell size

Curr Opin Genet Dev. 2002 Oct;12(5):565-71. doi: 10.1016/s0959-437x(02)00341-6.


Several genes involved in growth control have lately been demonstrated to exhibit more potent effects on cell size than on cell proliferation. Many of these genes direct protein and ribosomal synthesis, highlighting the interdependence between cell size and macromolecular content. The failure to maintain normal cell size when these genes are deregulated suggests that, in certain contexts, cell growth and division are not coupled or coordinated. Several physiological repercussions of altering cell size have been identified.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology
  • Cell Line, Transformed
  • Cell Size / physiology*
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / growth & development
  • Humans
  • Transcription Factors / physiology


  • Transcription Factors