Manganese-induced apoptosis in PC12 cells

Neurotoxicol Teratol. Sep-Oct 2002;24(5):639-53. doi: 10.1016/s0892-0362(02)00215-5.


Manganese has been known to induce neurological disorders similar to parkinsonisms for a long time. Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. However, the details of the mechanisms have yet to be elucidated. In an effort to learn more about the toxicity of manganese, we have employed an in vitro model that uses the PC12 catecholaminergic cell line. In this model, manganese induces apoptosis in PC12 cells. In this paper, experiments conducted with this model, the cellular biochemical changes, and the mechanism of the cell death are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Apoptosis / physiology
  • Humans
  • Manganese / adverse effects
  • Manganese / pharmacology*
  • Manganese Poisoning / metabolism*
  • Manganese Poisoning / physiopathology
  • Mitochondria / drug effects
  • Mitochondria / physiology
  • Models, Biological
  • Neurons / drug effects*
  • Neurons / metabolism
  • PC12 Cells / drug effects
  • PC12 Cells / metabolism
  • Parkinsonian Disorders / chemically induced*
  • Parkinsonian Disorders / metabolism
  • Parkinsonian Disorders / physiopathology
  • Rats
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Substantia Nigra / drug effects*
  • Substantia Nigra / metabolism
  • Substantia Nigra / physiopathology


  • Manganese