DNB: a partial D with anti-D frequent in Central Europe

Blood. 2002 Sep 15;100(6):2253-6. doi: 10.1182/blood-2002-03-0742.

Abstract

To improve routine D typing and define transfusion strategy, it is important to establish the frequency of partial D alleles and their susceptibility to anti-D alloimmunization due to transfusion or pregnancy. We identified the partial D DNB that was caused by an RHD(G355S) allele associated with a CDe haplotype and whose phenotype presented a normal D in routine typing. The antigen density was about 6000 D antigens per red blood cell, and the Rhesus index was 0.02. Five anti-D immunization events with allo-anti-D titers up to 128 were observed. Twelve carriers of DNB were whites of Central Europe; the only Danish proband had Austrian ancestry. DNB was the most frequent partial D recognized so far in whites, occurring with frequencies of up to 1:292 in Switzerland. DNB was the underlying partial D phenotype in a relevant fraction of anti-D immunizations occurring in whites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Blood Grouping and Crossmatching
  • Europe / epidemiology
  • Europe / ethnology
  • Gene Frequency
  • Haplotypes
  • Humans
  • Isoantibodies / blood*
  • Molecular Sequence Data
  • Point Mutation
  • Rh Isoimmunization / etiology
  • Rh-Hr Blood-Group System / blood
  • Rh-Hr Blood-Group System / genetics*
  • Rh-Hr Blood-Group System / immunology
  • Rho(D) Immune Globulin

Substances

  • Isoantibodies
  • RHO(D) antibody
  • Rh-Hr Blood-Group System
  • Rho(D) Immune Globulin
  • Rho(D) antigen

Associated data

  • GENBANK/AJ417868