Abstract
A novel alkaloid with an unprecedented fused-hexacyclic skeleton, daphmanidin A (1), and a new pentacyclic alkaloid, daphmanidin B (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was determined by combination of NOESY correlations and a modified Mosher method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Japan
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Leukemia
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Mice
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Molecular Conformation
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Molecular Structure
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Stereoisomerism
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Tumor Cells, Cultured / drug effects
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Heterocyclic Compounds, 4 or More Rings
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daphmanidin A
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daphmanidin B