Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer

Head Neck. 2002 Aug;24(8):792-9. doi: 10.1002/hed.10108.


Cyclooxygenase-2 (COX-2), an enzyme that catalyzes the synthesis of prostaglandins, is overexpressed in a variety of premalignant and malignant conditions, including oral leukoplakia and squamous cell carcinoma of the head and neck. Increased levels of COX-2 may contribute to carcinogenesis by modulating xenobiotic metabolism, apoptosis, immune surveillance, and angiogenesis. In experimental models, newly developed selective COX-2 inhibitors suppress the formation of tumors, including tongue cancer. These findings provided a rationale for a number of chemoprevention trials that are underway. Selective COX-2 inhibitors also suppress the growth and metastases of established tumors and enhance the anticancer activity of both radiotherapy and chemotherapy in experimental animals. In this review, evidence is presented that inhibition of COX-2 represents a promising strategy to prevent or possibly treat human head and neck cancers.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis / physiology
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / physiopathology
  • Carcinoma, Squamous Cell / prevention & control*
  • Cyclooxygenase Inhibitors / therapeutic use*
  • Head and Neck Neoplasms / drug therapy
  • Head and Neck Neoplasms / physiopathology
  • Head and Neck Neoplasms / prevention & control*
  • Humans
  • Immune Tolerance
  • Inflammation / metabolism
  • Neoplasm Invasiveness
  • Neoplasm Metastasis / drug therapy
  • Neovascularization, Pathologic / drug therapy
  • Neovascularization, Pathologic / metabolism
  • Prostaglandin-Endoperoxide Synthases / biosynthesis*
  • Sulfonamides / therapeutic use
  • Up-Regulation / physiology
  • Xenobiotics / metabolism


  • Cyclooxygenase Inhibitors
  • Sulfonamides
  • Xenobiotics
  • Prostaglandin-Endoperoxide Synthases
  • nimesulide