The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development

Mech Dev. 2002 Sep;117(1-2):265-8. doi: 10.1016/s0925-4773(02)00176-4.

Abstract

The Drosophila C(2)-H(2)-type zinc-finger transcription factor CF2 has been shown to regulate follicular cell fate determination during oogenesis. Here we show that CF2 is also expressed in the developing muscles of the embryo where it first appears at stage 12 at the time of skeletal myoblast fusion. Later it is expressed in all muscle lineages including skeletal, visceral and cardiac. Epistatic analysis showed that CF2 expression is dependent on the myogenic factor MEF2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Drosophila / embryology*
  • Drosophila / genetics*
  • Drosophila / metabolism
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism
  • Gene Expression Regulation, Developmental
  • Genes, Insect
  • Immunohistochemistry
  • MEF2 Transcription Factors
  • Muscles / embryology*
  • Muscles / metabolism*
  • Myogenic Regulatory Factors
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Zinc Fingers / genetics

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • MEF2 Transcription Factors
  • Mef2 protein, Drosophila
  • Myogenic Regulatory Factors
  • Transcription Factors
  • Cf2 protein, Drosophila