Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

Mech Dev. 2002 Sep;117(1-2):289-92. doi: 10.1016/s0925-4773(02)00182-x.


We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / growth & development*
  • Caenorhabditis elegans Proteins / genetics*
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental
  • Genes, Helminth*
  • Green Fluorescent Proteins
  • Luminescent Proteins / genetics
  • Mice
  • Molecular Sequence Data
  • Recombinant Fusion Proteins / genetics
  • Sequence Homology, Amino Acid


  • Caenorhabditis elegans Proteins
  • Luminescent Proteins
  • Recombinant Fusion Proteins
  • Green Fluorescent Proteins