Molecular interactions in biofilms

Chem Biol. 2002 Aug;9(8):859-71. doi: 10.1016/s1074-5521(02)00198-9.


A biofilm may be defined as a microbially derived, sessile community characterized by cells that attach to an interface, embed in a matrix of exopolysaccharide, and demonstrate an altered phenotype. This review covers the current understanding of the nature of biofilms and the impact that molecular interactions may have on biofilm development and phenotype using the motile gram-negative rod Pseudomonas aeruginosa and the nonmotile gram-positive cocci Staphylococcus aureus as examples.

Publication types

  • Review

MeSH terms

  • Biofilms / growth & development*
  • Cell Communication / genetics
  • Gene Expression Regulation, Bacterial
  • Phenotype
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / growth & development
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / growth & development