Reinterpreting the pressure-volume curve in patients with acute respiratory distress syndrome

Curr Opin Crit Care. 2002 Feb;8(1):32-8. doi: 10.1097/00075198-200202000-00006.


New evidence requires a reinterpretation of the inflation pressure-volume curve and suggests that neither the lower nor the upper inflection point provides reliable information to determine safe ventilator settings in the acute respiratory distress syndrome. Recruitment probably continues throughout the inflation pressure-volume curve, and studies of the deflation pressure-volume curve, reinflations after partial deflation, or decremental positive end-expiratory pressure trials after a recruitment maneuver are probably needed to determine open-lung positive end-expiratory pressure.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lung Compliance
  • Lung Volume Measurements
  • Positive-Pressure Respiration / methods*
  • Respiratory Distress Syndrome / physiopathology*
  • Respiratory Distress Syndrome / therapy
  • Respiratory Mechanics / physiology*