Erythritol attenuates the diabetic oxidative stress through modulating glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats

J Agric Food Chem. 2002 Sep 11;50(19):5485-9. doi: 10.1021/jf020168z.


We investigated the effects of erythritol on rats with streptozotocin- (STZ-) induced diabetes mellitus. Oral administration of erythritol [100, 200, or 400 mg (kg body weight)(-1) day(-1) for 10 days] to rats with STZ-induced diabetes resulted in significant decreases in the glucose levels of serum, liver, and kidney. Erythritol also reduced the elevated serum 5-hydroxymethylfurfural level that is glycosylated with protein as an indicator of oxidative stress. In addition, thiobarbituric acid-reactive substance levels of serum and liver and kidney mitochondria were dose-dependently lower in the erythritol-treated groups than in the control diabetic group. Furthermore, the serum creatinine level was reduced by oral administration of erythritol in a dose-dependent manner. These results suggest that erythritol affects glucose metabolism and reduces lipid peroxidation, thereby improving the damage caused by oxidative stress involved in the pathogenesis of diabetes.

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Blood Glucose / metabolism*
  • Blood Proteins / metabolism
  • Body Weight / drug effects
  • Creatinine / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Erythritol / pharmacology
  • Erythritol / therapeutic use*
  • Glucose / analysis
  • Glycosylation
  • Kidney / chemistry
  • Kidney / ultrastructure
  • Lipid Peroxidation / drug effects
  • Liver / chemistry
  • Male
  • Mitochondria / chemistry
  • Mitochondria, Liver / chemistry
  • Organ Size / drug effects
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar
  • Thiobarbituric Acid Reactive Substances / analysis


  • Blood Glucose
  • Blood Proteins
  • Thiobarbituric Acid Reactive Substances
  • Creatinine
  • Alanine Transaminase
  • Glucose
  • Erythritol