A case of Sézary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma

Br J Dermatol. 2002 Sep;147(3):582-6. doi: 10.1046/j.1365-2133.2002.04839.x.


Sézary's syndrome (SS) is a leukaemic variant of mycosis fungoides, a cutaneous T-cell lymphoma showing distinct clinical, histological, immunological, and genotypic features. We report a 10-year follow-up of a patient with SS exhibiting unusual features such as granulomatous skin lesions, transformation to a CD30-positive large-cell pleomorphic T-cell lymphoma, and development of myelodysplastic syndrome and review the cases of SS reported in the literature with these unusual and rare complications.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Fatal Outcome
  • Female
  • Follow-Up Studies
  • Granuloma / pathology
  • Humans
  • Ki-1 Antigen / analysis
  • Lymphoma, Non-Hodgkin / pathology*
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Middle Aged
  • Myelodysplastic Syndromes / pathology
  • Sezary Syndrome / pathology*
  • Skin Neoplasms / pathology*


  • Ki-1 Antigen