Hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma

Br J Dermatol. 2002 Sep;147(3):587-91. doi: 10.1046/j.1365-2133.2002.04862.x.


An 8-year-old Taiwanese girl had a 6-month history of a relapsing papulovesicular eruption on her face that resembled hydroa vacciniforme (HV). Histologically, there was a dense infiltration of large atypical lymphocytic cells expressing CD8. TCR-gamma gene rearrangement study revealed a monoclonal band present in the DNA extracted from the specimen. A diagnosis of CD8+ cutaneous T-cell lymphoma (CTCL) was made. The patient was treated with Chinese herbal drugs and her skin lesions waxed and waned. At this writing, 11 months after establishment of the diagnosis, the skin lesions have been limited to the facial area and no definite evidence of systemic involvement is noted. To our knowledge, this is the first case of CD8+ primary CTCL with clinical features resembling HV.

Publication types

  • Case Reports
  • Review

MeSH terms

  • CD8-Positive T-Lymphocytes / pathology
  • Child
  • Facial Dermatoses / complications*
  • Facial Dermatoses / pathology
  • Female
  • Humans
  • Hydroa Vacciniforme / complications*
  • Hydroa Vacciniforme / pathology
  • Lymphoma, T-Cell, Cutaneous / complications*
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Skin Neoplasms / complications*
  • Skin Neoplasms / pathology