The influence of age and sex on skin thickness, skin collagen and density

Br J Dermatol. 1975 Dec;93(6):639-43. doi: 10.1111/j.1365-2133.1975.tb05113.x.


Forearm skin collagen, dermal thickness and collagen density were measured in a large number of normal subjects as a standard reference for future studies. Skin collagen decreased with age and was less in the females at all ages. There is a direct relationship between skin collagen and dermal thickness but variations in collagen density in disease limit the use of dermal thickness as a guide to changes in its collagen content.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Collagen / analysis*
  • Female
  • Forearm / anatomy & histology
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Skin / analysis
  • Skin / anatomy & histology*


  • Collagen