Seven-transmembrane receptors

Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50. doi: 10.1038/nrm908.


Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Dimerization
  • Down-Regulation
  • Heterotrimeric GTP-Binding Proteins / metabolism
  • Humans
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / classification
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Yeasts


  • Receptors, Cell Surface
  • Heterotrimeric GTP-Binding Proteins