Stats: transcriptional control and biological impact

Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62. doi: 10.1038/nrm909.


Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Janus Kinase 1
  • Models, Molecular
  • Phosphorylation
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Protein Transport
  • Protein-Tyrosine Kinases / metabolism
  • STAT1 Transcription Factor
  • Signal Transduction
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism*
  • Transcription, Genetic*


  • DNA-Binding Proteins
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • Janus Kinase 1