Mixed-lineage kinase control of JNK and p38 MAPK pathways

Nat Rev Mol Cell Biol. 2002 Sep;3(9):663-72. doi: 10.1038/nrm906.


Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Dimerization
  • Humans
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Signaling System*
  • Mitogen-Activated Protein Kinases / metabolism*
  • Phosphorylation
  • Protein Serine-Threonine Kinases / chemistry
  • Protein Serine-Threonine Kinases / classification
  • Protein Serine-Threonine Kinases / metabolism*
  • p38 Mitogen-Activated Protein Kinases
  • rho GTP-Binding Proteins / metabolism
  • src Homology Domains


  • Protein Serine-Threonine Kinases
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases
  • p38 Mitogen-Activated Protein Kinases
  • rho GTP-Binding Proteins