Listening in on Bacteria: Acyl-Homoserine Lactone Signalling

Nat Rev Mol Cell Biol. 2002 Sep;3(9):685-95. doi: 10.1038/nrm907.

Abstract

Bacterial cell-to-cell signalling has emerged as a new area in microbiology. Individual bacterial cells communicate with each other and co-ordinate group activities. Although a lot of detail is known about the mechanisms of a few well-characterized bacterial communication systems, other systems have been discovered only recently. Bacterial intercellular communication has become a target for the development of new anti-virulence drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / biosynthesis
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / metabolism*
  • Animals
  • Bacteria / cytology
  • Bacteria / enzymology
  • Bacteria / metabolism*
  • Bacteria / pathogenicity
  • Biofilms
  • Bioterrorism
  • Luminescent Measurements
  • Repressor Proteins / chemistry
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Signal Transduction*
  • Symbiosis
  • Trans-Activators / chemistry
  • Trans-Activators / genetics
  • Trans-Activators / metabolism

Substances

  • Repressor Proteins
  • Trans-Activators
  • LuxR autoinducer binding proteins
  • homoserine lactone
  • 4-Butyrolactone