Signalling shortcuts: cell-surface receptors in the nucleus?

Nat Rev Mol Cell Biol. 2002 Sep;3(9):697-702. doi: 10.1038/nrm905.


Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.

Publication types

  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cell Nucleus / metabolism*
  • ErbB Receptors / metabolism
  • Humans
  • Ligands
  • Models, Biological
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction*


  • Ligands
  • Receptors, Cell Surface
  • ErbB Receptors