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, 1 (9), 727-30

The Druggable Genome


The Druggable Genome

Andrew L Hopkins et al. Nat Rev Drug Discov.


An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a good drug target.

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