Therapeutic effects of psyllium in type 2 diabetic patients

Eur J Clin Nutr. 2002 Sep;56(9):830-42. doi: 10.1038/sj.ejcn.1601398.

Abstract

Objective: The aim of this study was to evaluate the effects of psyllium in type 2 diabetic patients.

Design: The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre/day, 6 weeks) and phase 3 (4 weeks). At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal). Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA(1c), C-peptide and 24 h urinary glucose excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated.

Setting: The study was performed at the Department of Pharmacology, Toxicology and Nursing at the University of León (Spain).

Subjects: Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men and 66 y for women. The mean body mass index of men was 28.2 kg/m(2) and that of women 25.9 kg/m(2).

Results: Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an important change in insulin levels (5%). GHbA(1c), C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%, respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences). Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%, significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after psyllium administration.

Conclusions: The results obtained indicate a beneficial therapeutic effect of psyllium (Plantaben) in the metabolic control of type 2 diabetics as well as in lowering the risk of coronary heart disease. We also conclude that consumption of this fibre does not adversely affect either mineral or vitamin A and E concentrations. Finally, for a greater effectiveness, psyllium treatment should be individually evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Glucose / drug effects
  • C-Peptide / blood
  • C-Peptide / drug effects
  • C-Peptide / urine
  • Cholesterol / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Female
  • Fructosamine / blood
  • Glycated Hemoglobin A / drug effects
  • Glycosuria / urine
  • Humans
  • Insulin / blood
  • Male
  • Middle Aged
  • Minerals / blood
  • Psyllium / therapeutic use*
  • Time Factors
  • Vitamins / blood

Substances

  • Blood Glucose
  • C-Peptide
  • Glycated Hemoglobin A
  • Insulin
  • Minerals
  • Vitamins
  • Fructosamine
  • Psyllium
  • Cholesterol