Histological examination of beta-tricalcium phosphate graft in human femur

J Biomed Mater Res. 2002;63(5):601-4. doi: 10.1002/jbm.10380.


Prominent osteoconductive activity and the biodegradable nature of beta tricalcium phosphate (beta-TCP) for bone grafts in animal experiments has been reported. A new type of beta-TCP has been manufactured at extraordinarily high purity and has been available as potent bone grafting substitute for clinical use. The histological features of grafted beta-TCP in human bone have been analyzed. A 33-year-old female with a bone tumor of the proximal femur underwent curettage and beta-TCP graft under the diagnosis of probable benign fibrous dysplasia. Four weeks later, the proximal femur, including the grafted beta-TCP was resected because of the final diagnosis of the curettaged materials was osteosarcoma. The resected specimen revealed abundant direct new bone apposition on beta-TCP. There was no cartilaginous tissue or enchondral ossification. Bone formation was more prominent in the periphery of the grafted area than in the center. There was a considerable number of osteoclast-like giant cells surrounding the beta-TCP. This case illustrated that highly purified beta-TCP had prominent osteoconductive activity and biodegradable nature in human bone.

Publication types

  • Case Reports

MeSH terms

  • Absorbable Implants
  • Adult
  • Animals
  • Bone Regeneration*
  • Bone Substitutes*
  • Calcium Phosphates*
  • Female
  • Femoral Neoplasms / surgery
  • Femur / diagnostic imaging
  • Femur / surgery*
  • Humans
  • Osseointegration / physiology
  • Osteosarcoma / surgery
  • Prostheses and Implants
  • Radiography


  • Bone Substitutes
  • Calcium Phosphates
  • beta-tricalcium phosphate
  • tricalcium phosphate