When machines get stuck--obstructed RNA polymerase II: displacement, degradation or suicide

Bioessays. 2002 Sep;24(9):780-4. doi: 10.1002/bies.10150.


The severe hereditary progeroid disorder Cockayne syndrome is a consequence of a defective transcription-coupled repair (TCR) pathway. This special mode of DNA repair aids a RNA polymerase that is stalled by a DNA lesion in the template and ensures efficient DNA repair to permit resumption of transcription and prevent cell death. Although some key players in TCR, such as the Cockayne syndrome A (CSA) and B (CSB) proteins have been identified, the exact molecular mechanism still remains illusive. A recent report provides new unexpected insights into TCR in yeast. The identification and characterisation of a novel protein co-purifying with the yeast homologue of CSB (Rad26) imposes reassessment of our current understanding of TCR in yeast. What about humans?

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins*
  • Chromosomal Proteins, Non-Histone / metabolism
  • DNA Repair
  • Fungal Proteins / metabolism
  • Humans
  • Models, Biological
  • RNA Polymerase II / metabolism*
  • RNA Polymerase II / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Schizosaccharomyces pombe Proteins*
  • Transcription, Genetic


  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DEF1 protein, S cerevisiae
  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • rad26 protein, S pombe
  • RNA Polymerase II