Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

Ann Neurol. 2002 Aug;52(2):205-10. doi: 10.1002/ana.10279.


Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • Corpus Striatum / metabolism*
  • Corpus Striatum / pathology*
  • Humans
  • Lewy Body Disease / metabolism*
  • Lewy Body Disease / pathology*
  • Molecular Weight
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / immunology
  • Nerve Tissue Proteins / metabolism*
  • Nitrates / metabolism
  • Peptide Fragments / metabolism
  • Synucleins
  • alpha-Synuclein


  • Antibodies, Monoclonal
  • Nerve Tissue Proteins
  • Nitrates
  • Peptide Fragments
  • SNCA protein, human
  • Synucleins
  • alpha-Synuclein