Volume of rat lungs measured throughout the respiratory cycle using 19F NMR of the inert gas SF6

Magn Reson Med. 2002 Sep;48(3):547-9. doi: 10.1002/mrm.10245.


The lung volumes of mechanically ventilated rats were measured over the course of the respiratory cycle using the NMR signal strength from inhaled sulfurhexafluoride. Rats with elastase-induced emphysema showed larger lung volumes and slower exhalation than control rats. For humans the technique should be able to provide lung volume measurements at least 20 times a second.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Fluorine
  • Lung Volume Measurements*
  • Magnetic Resonance Spectroscopy / methods*
  • Pancreatic Elastase
  • Pulmonary Emphysema / physiopathology*
  • Rats
  • Rats, Sprague-Dawley
  • Sulfur Hexafluoride / administration & dosage


  • Fluorine
  • Pancreatic Elastase
  • Sulfur Hexafluoride