Transforming growth factor-beta1 negatively regulates crystallin expression in teeth

J Bone Miner Res. 2002 Sep;17(9):1710-7. doi: 10.1359/jbmr.2002.17.9.1710.


Previously, we have reported that targeted overexpression of transforming growth factor (TGF) beta1 in the teeth of the transgenic mice (dTGF-beta1) results in a novel tooth phenotype phenomimicking the most prevalent tooth disorders in human. This phenotype was associated with discoloration and attrition of teeth due to defective mineralization. Here, we report a novel expression of crystallin family members in developing mouse teeth and its regulation by TGF-beta1 in these transgenic mice. AlphaB- and beta-crystallins were found to be elevated in dTGF-beta1 mouse teeth, whereas gamma-crystallin (gammaB, gammaC, and gammaF), a marker of cell differentiation, was significantly reduced. Because crystallins are believed to be stress-related proteins, their expression in teeth implicates them in a similar role because teeth are constantly subjected to physical friction and temperature fluctuations.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Crystallins / genetics*
  • Crystallins / physiology
  • Dentin Dysplasia / etiology
  • Dentin Dysplasia / genetics
  • Dentinogenesis Imperfecta / etiology
  • Dentinogenesis Imperfecta / genetics
  • Gene Expression
  • Humans
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Odontogenesis / genetics
  • Odontogenesis / physiology
  • Phenotype
  • Proteome
  • RNA / genetics
  • RNA / metabolism
  • Tooth / physiology*
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / physiology*
  • Transforming Growth Factor beta1


  • Crystallins
  • Proteome
  • TGFB1 protein, human
  • Tgfb1 protein, mouse
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • RNA