[Effects of cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B]

Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):248-50.
[Article in Chinese]


In order to find an effective drug to cure patients with chronic hepatitis B, cordyceps sinensis had been used to treat 25 patients with chronic hepatitis B. The comprehensive index, including T lymphocyte subsets (CD4, CD8), hyaluronic acid(HC) and precollagen type III(PC III), were observed before and after treatment. After 3 months of treatment, CD4 and CD4/CD8 ratio increased significantly(P < 0.05), while HA and PC III decreased significantly(P < 0.05) compared with the control. The results suggest that the beneficial effects might be obtained by using cordyceps sinensis to adjust the T lymphocyte subsets level and to treat hepatic fibrosis on patients with chronic hepatitis B.

MeSH terms

  • Adolescent
  • Adult
  • CD4-CD8 Ratio
  • Collagen Type III / blood
  • Cordyceps / chemistry*
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Hepatitis B, Chronic / drug therapy*
  • Hepatitis B, Chronic / immunology
  • Hepatitis B, Chronic / pathology
  • Humans
  • Hyaluronic Acid / blood
  • Liver Cirrhosis / prevention & control*
  • Male
  • Middle Aged
  • T-Lymphocyte Subsets / immunology*


  • Collagen Type III
  • Drugs, Chinese Herbal
  • Hyaluronic Acid